Acetanilide

Acetanilide is odorless substance in a leaflet or flake form. Acetanilide is also known as N-phenylacetamide, Acetanil, or acetanilid, and was formerly known by the trade name antifebrin. This compound is soluble in hot water and has the ability to self-ignite if it reaches a temperature of 545 °C.

Applications

Acetanilide is used as an inhibitor in hydrogen peroxide and is used to stabilize cellulose ester varnishes. It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide was used as a precursor in penicillin synthesis and other pharmaceuticals and its intermediates.

Acetanilide has analgesic and fever-reducing properties; it is in the same class of drugs as acetaminophen or paracetamol. Under the name acetanilid it formerly figured in the formula of a number of patent medicines and over the counter drugs. In 1948, Julius Axelrod and Bernard Brodie discovered that acetanilide is much more toxic in these applications than other drugs, causing methemoglobinemia and ultimately doing damage to the liver and kidneys. As such, acetanilide has largely been replaced by less toxic drugs.

In the 19th century it was one of a large number of compounds used as experimental photographic developers