Elimination half-life

The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes.

Half-life is an important pharmacokinetic parameter and is usually denoted by the abbreviation t_1/2.

Half-life in first-order elimination

This process is usually a first-order logarithmic process - that is, a constant proportion of the agent is eliminated per unit time (Birkett, 2002). Thus the fall in plasma concentration after the administration of a single dose is described by the following equation:

• C_t is concentration after time t
• C₀ is the initial concentration (t=0)
• k is the elimination rate constant

The relationship between the elimination rate constant and half-life is given by the following equation:

Half-life is determined by clearance (CL) and volume of distribution (V_D) and the relationship is described by the following equation:

Half-life in zero-order elimination

There are circumstances where the half-life varies with the concentration of the drug. For example, ethanol may be consumed in sufficient quantity to saturate the metabolic enzymes in the liver, and so is eliminated from the body at an approximately constant rate (zero-order elimination). Thus the half-life, under these circumstances, is proportional to the initial concentration of the drug A₀ and inversely proportional to the zero-order rate constant k₀ where:

References

Birkett DJ (2002). Pharmacokinetics Made Easy (Revised Edition). Sydney: McGraw-Hill Australia. ISBN 0-07-471072-9.